home *** CD-ROM | disk | FTP | other *** search
- $Unique_ID{BRK03234}
- $Pretitle{}
- $Title{metolazone}
- $Subject{Diulo Searle Microx Pennwalt Zaroxolyn Diuretic antihypertensive
- metolazone high blood pressure fluid accumulation heart failure cirrhosis
- liver kidney disease elimination salt water kidneys}
- $Volume{}
- $Log{
- Diulo 2.5 mg*0323401.scf
- Diulo 5 mg*0323402.scf}
-
- Copyright (C) 1993 Publications International, Ltd.
-
-
- metolazone
- ------------------------------------------------------------------------------
-
- BRAND NAMES (Manufacturers)
-
- Diulo (Searle)
- Microx (Pennwalt)
- Zaroxolyn (Pennwalt)
-
- TYPE OF DRUG
-
- Diuretic and antihypertensive
-
- INGREDIENT
-
- metolazone
-
- DOSAGE FORM
-
- Tablets (2.5 mg, 5 mg, and 10 mg)
-
- STORAGE
-
- This medication should be stored at room temperature in a tightly closed
- container.
-
- USES
-
- Metolazone is prescribed to treat high blood pressure. It is also used
- to reduce fluid accumulation in the body caused by conditions such as heart
- failure, cirrhosis of the liver, kidney disease, and the long-term use of some
- medications. Metolazone reduces fluid accumulation by increasing the
- elimination of salt and water through the kidneys.
-
- TREATMENT
-
- To decrease stomach irritation, you can take this medication with a glass
- of milk or with a meal (unless your doctor directs you to do otherwise). Try
- to take it at the same time every day. Avoid taking a dose after 6:00 p.m.;
- otherwise, you may have to get up during the night to urinate.
- If you miss a dose of this medication, take the missed dose as soon as
- possible, unless it is almost time for the next dose. In that case, do not
- take the missed dose at all; just wait until the next scheduled dose. Do not
- double the dose.
- This medication does not cure high blood pressure, but it will help to
- control the condition as long as you take it.
-
- SIDE EFFECTS
-
- Minor.
-
- Constipation, cramps, diarrhea, dizziness, drowsiness, headache,
- heartburn, loss of appetite, restlessness, or upset stomach. As your body
- adjusts to the medication, these side effects should disappear.
- This medication can cause increased sensitivity to sunlight. It is,
- therefore, important to avoid prolonged exposure to sunlight and sunlamps.
- Wear protective clothing, and use an effective sunscreen.
- To relieve constipation, increase the amount of fiber in your diet (fresh
- fruits and vegetables, salads, bran, and whole-grain breads) and exercise more
- (unless your doctor directs you to do otherwise).
- To avoid dizziness or light-headedness when you stand, contract and relax
- the muscles of your legs for a few moments before rising. Do this by pushing
- one foot against the floor while raising the other foot slightly, alternating
- feet so that you are "pumping" your legs in a pedaling motion. Also, be very
- careful going up and down the stairs.
-
- Major.
-
- Tell your doctor about any side effects that are persistent or
- particularly bothersome. IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
- blurred vision, confusion, difficulty in breathing, dry mouth, excessive
- thirst, excessive weakness, fever, itching, joint pain, mood changes, muscle
- spasms, nausea, palpitations, skin rash, sore throat, tingling in the fingers
- or toes, unusual bleeding or bruising, vomiting, or yellowing of the eyes or
- skin.
-
- INTERACTIONS
-
- Metolazone interacts with several other types of drugs:
- 1. It may decrease the effectiveness of oral anticoagulants, antigout
- medications, insulin, oral antidiabetic medicines, and methenamine.
- 2. Fenfluramine can increase the blood-pressure-lowering effects of
- metolazone (which can be dangerous).
- 3. Indomethacin can decrease the blood-pressure-lowering effects of
- metolazone, and counteract the desired effects.
- 4. Cholestyramine and colestipol decrease the absorption of this
- medication from the gastrointestinal tract. Metolazone should, therefore, be
- taken one hour before or four hours after a dose of cholestyramine or
- colestipol (if you have also been prescribed one of these medications).
- 5. The side effects of amphotericin B, calcium, cortisone and
- cortisone-like steroids (such as dexamethasone, hydrocortisone, prednisone,
- and prednisolone), digitalis, digoxin, lithium, quinidine, sulfonamide
- antibiotics, and vitamin D may be increased when these drugs are taken
- concurrently with metolazone.
- Before starting to take metolazone, BE SURE TO TELL YOUR DOCTOR about any
- medications you are currently taking, especially any of those listed above.
-
- WARNINGS
-
- * Tell your doctor about unusual or allergic reactions you have had to
- any medications, especially to metolazone or to any other sulfa drugs,
- including other diuretics, oral antidiabetic medications, or sulfonamide
- antibiotics.
- * Tell your doctor if you now have or if you have ever had kidney disease
- or problems with urination, diabetes mellitus, gout, liver disease, asthma,
- pancreatic disease, or systemic lupus erythematosus.
- * Metolazone can cause potassium loss. Signs of potassium loss include
- dry mouth, thirst, weakness, muscle pain or cramps, nausea, and vomiting. If
- you experience any of these symptoms, call your doctor. To help avoid
- potassium loss, take this drug with a glass of fresh or frozen orange juice or
- cranberry juice, or eat a banana every day. The use of a salt substitute also
- helps to prevent potassium loss. Do not change your diet or use a salt
- substitute, however, before discussing it with your doctor. Too much
- potassium can also be dangerous. Your doctor may want to have blood tests
- performed periodically to monitor your potassium levels.
- * Limit your intake of alcoholic beverages while taking this medication,
- in order to prevent dizziness.
- * Do not take any over-the-counter (nonprescription) medications for
- weight control or for cough, cold, allergy, asthma, or sinus problems unless
- your doctor directs you to do so. Some of these products can increase blood
- pressure.
- * To prevent dehydration (severe water loss) while taking this
- medication, check with your doctor if you have any illness that causes severe
- or continuous nausea, vomiting, or diarrhea.
- * This medication can raise blood sugar levels in diabetic patients.
- Therefore, blood sugar levels should be carefully monitored by blood or urine
- tests when this medication is being taken.
- * Be sure to tell your doctor if you are pregnant. Metolazone can cross
- the placenta and may cause adverse effects in the fetus. Also, tell your
- doctor if you are breast-feeding an infant. Although problems in humans have
- not been reported, small amounts of this drug can pass into breast milk, so
- caution is warranted.
-
- ----------------
-
- The material contained here is "FOR INFORMATION ONLY" and should not replace
- the counsel and advice of your personal physician. Promptly consulting your
- doctor is the best path to a quick and successful resolution of any medical
- problem.
-